Various aspects of Baltimore life have been depicted in movies and TV:
Jewish Baltimore: Barry Levinson
http://en.wikipedia.org/wiki/Barry_Levinson
Weird White "Hon" Baltimore: John Waters
http://en.wikipedia.org/wiki/John_Waters
Gritty Urban Baltimore: The Wire (David Simon) TV series
http://en.wikipedia.org/wiki/The_Wire
Roc TV series - not sure how to describe this one as it's been a long time since I watched it, but it's about a garbage collector in Baltimore-
http://en.wikipedia.org/wiki/Roc_(TV_series)
And I'm sure there's more that I'm leaving out. This post will be updated when I think of more!