Barisal was a semi-independent area in the Mughal period because of heavy fighting between them and Hindu chiefs, the last being Raja Nakuleswar Bose. In course of time, it fell under Bengal Nawabs and British India, later passed to Bangladesh.

The central city of this region is the city of Barisal. It is one of the biggest river ports in Bangladesh. It is a city with nearly 0.38 million people and a divisional headquarters, medical college, cadet college, some pharmaceutical industries, textile industries and the Bangladesh Inland Water Transport Authority's head office. Barisal is fast growing city of the country stands on the Kirtankhola River. Country's first short landing and take off airport has been completed in Barisal and a private Airlines named Air Bengal has begun its regular air flight between Dhaka Tejgaon Airport and Barisal.

The city is sometimes called the "Venice of the East" or the "Venice of Bengal".^[5]