This is really a fantastic subject that there are many similarities with BRCA1 genes on breast cancer. I have noted those points with numbering. I think it will be a great point to the readers and I will know this on comment box.  A application for the isolated BRCA1 factor and cancer-cancer promoting mutations, furthermore as strategies to diagnose the chance of obtaining carcinoma, was filed by the University of UT, National Institute of Environmental Health Sciences (NIEHS) and Myriad genetic science in 1994;[11] over succeeding year, Myriad, together with alternative investigators, isolated and sequenced the BRCA2 factor and known relevant mutations, and therefore the initial BRCA2 patent was filed within the U.S. by Myriad and therefore the alternative establishments in 1995.[10] Myriad is that the exclusive licensee of those patents and has implemented them within the United States against clinical diagnostic labs.[14] This business model semiconductor diode from Myriad being a startup in 1994 to being a publically listed company with 1200 workers and concerning $500M in annual revenue in 2012;[13] it additionally semiconductor diode to disputation over high costs and therefore the inability to induce second opinions from alternative investigation centre on BRCA and  the landmark Association for Molecular Pathology v. Myriad genetic science proceedings.[14][71] The patents begin to expire in 2014.