The site was effectively closed to tourists for several years because of guerrilla activity in the region along with concerns about the impact of unregulated tourist traffic. It was reopened to visitors in 2009, and today there are several Colombian Tourist Agencies that will fly travelers to La Macarena. From there, they must make their way to the river site on horseback (or donkeyback) and by foot as part of a guided tour.

Visitors are not permitted to stay overnight or cook. For see Caño Cristales, it is necessary to travel to the municipality of La Macarena, Meta, in Meta Department. There are two ways to get there, from Villavicencio, in a DC-3 cargo aircraft coming out every day, or from Bogota