The BRCA OB1 domain assumes associate degree OB fold that consists of an extremely wiggly five-stranded beta-sheet that closes on itself to make a beta-barrel. OB1 includes a shallow groove fashioned by one face of the wiggly sheet and is demarcated by 2 loops, one between beta one and beta two and another between beta four and beta five, that permits for weak single strand deoxyribonucleic acid binding. The domain conjointly binds the 70-amino acid DSS1 (deleted in split-hand/split foot syndrome) super molecule.[68]

The BRCA OB3 domain assumes associate degree OB fold, that consists of a extremely wiggly five-stranded beta-sheet that closes on itself to make a beta-barrel. OB3 includes a pronounced groove fashioned by one face of the wiggly sheet and is demarcated by 2 loops, one between beta one and beta two and another between beta four and beta five, that permits for robust ssDNA binding.[68]

 

The Tower domain adopts a secondary structure consisting of a try of long, parallel alpha-helices (the stem) that support a three-helix bundle (3HB) at their finish. The 3HB contains a helix-turn-helix motif and is analogous to the deoxyribonucleic acid binding domains of the microorganism site-specific recompenses, and of organism my and home domain transcription factors. The Tower domain has a very important role within the neoplasm suppressor perform of BRCA2, and is important for applicable binding of BRCA2 to deoxyribonucleic acid.[68]