is the only female member of the Shichibukai. She is also the "Snake Princess" of Amazon Lily and rules over the Kuja tribe with her two younger Gorgon sisters, Boa Sandersonia and Boa Marigold. She is the main antagonist of the Amazon Lily Arc.

Because of her beauty and strength, she is used to seeing men and women, young and old alike, fall instantly in love with her. As a result, people forgive her when she acts cutely apologetic or reminds them of her beauty. However, when Luffy came along and displayed a complete immunity to her charms, she initially felt that she could not bear the existence of someone completely invulnerable to her powers, and would collapse dramatically whenever insulted. This feeling has eroded away, though, as she loves Luffy despite his immunity to her. Even after the two year timeskip, Hancock continues to be in love with Luffy as much as before despite that the latter openly rejected a wedding proposal from her.

Trivia:
She is one of the two women who so far have claimed to be the "most beautiful", the other being Alvida. Both of these women have grown infatuated with Luffy, though Hancock is perhaps the first character in the entire series who has shown feelings identified as romantic love, unlike Alvida, whose feelings for Luffy resemble more of an "admiring love" since Luffy was the first (and only) man to ever punch her. According to Sanji, Shirahoshi has been rumored to be even more beautiful than Boa herself.