The University of California, San Diego Library consists of the Geisel Librarybuilding and the Biomedical Library building. There are also three off-campus locations: The Scripps Archives and Library Annex (available by appointment), the Annex (collections available by request), and the UC Southern Regional Library Facility (collections available by request).

The Geisel Library building contains materials and services related to: Arts, Area Studies, Engineering, Humanities, Marine Sciences, Physical Sciences, and Social Sciences. It also contains the Mandeville Special Collections & Archives, which houses the Dr. Seuss Collection. The Dr. Seuss Collection contains original drawings, sketches, proofs, notebooks, manuscript drafts, books, audio and videotapes, photographs, and memorabilia. The approximately 8,500 items in the collection document the full range of Dr. Seuss's creative achievements, beginning in 1919 with his high school activities and ending with his death in 1991.